Help us transform patients' lives.

At UCB, we put our heart, soul and skills into making a difference for people living with severe diseases.  Working together to push the boundaries, we blend the best of our talents to unlock innovation. Will you join us in this pioneering adventure? 

Neuro-pharmacologist for the Neuroscience Partnering team

Location: Braine-l’Alleud

Help us transform patients’ lives. At UCB, we put our heart, soul and skills into making a difference for people living with severe disease. Working together to push the boundaries, we blend the best of our talents to unlock innovation. Will you join us in our pioneering adventure ?

UCB is a leading global biopharmaceutical company developing innovative therapies to address unmet needs of patients suffering from severe disorders. The company’s global R&D organization “Early Solutions” is responsible from early research up to clinical Proof of Concept and focused on two main Therapeutic Areas, Immunology and Neurology. Immunology is based in Slough UK, while Neurology is based in Braine-l’Alleud, Belgium, close to the company Headquarter located in Brussels.

UCB New Medicines is recruiting for the site in Braine-L’Alleud a (m/f):

Neuro-pharmacologist for the Neuroscience Partnering team

Nature and Scope:

We are currently hiring a talented, senior in vitro or in vivo Neuro-pharmacologist to join the Neuroscience Partnering Team, which reports to the VP - Neuroscience TA, based in Braine L’Alleud, Belgium. At the interface between internal R&D, external R&D in pharma, biotech and academia and business development the Neuroscience Partnering Team plays a critical role in the development of our pipeline and provides a dynamic and stimulating environment for drug hunters.

The remits of the group include but are not limited to searching, evaluating and facilitating in-licensing of external and innovative drug discovery and development programs in order to enrich the Neuroscience portfolio. Also included are contributions to business negotiations, set-up of research programs and organizing alliance management at early stages of the collaborations. In order to achieve these goals, the group has access to a large panel of experts, available within or outside the organization.

To further strengthen our team, we are seeking a senior neuro-biologist or neuro-pharmacologist with a significant experience in discovery of drugs in the neurology area. Experience in the new therapeutic modalities such as viral gene-therapy is a plus.

Using his/her network, connections in meetings and available databases, the candidate will scout amidst pharmaceutical companies or academia for possible external assets or programs matching our strategic interests.

The function will also include acting as the due diligence expert lead/coordinator within a large DD team, with the aim to pro-actively provide recommendations to decision committees.

In this capacity, he/she will be autonomous in: (i) critically assessing results of in vivo and in vitro experiments; and (ii) provide a broader recommendation on opportunities by assembling an integrated view point.

Education, Experience &  Skills

The ideal candidate will have acquired his/her PhD in the field(s) of Neuroscience/Neuropharmacology, together with a postdoc in the field and 10 years experiences in a bio-pharmaceutical environment. A thorough understanding of different phases in pre-clinical drug discovery and hands-on project management is essential.

The candidate will

•            Have built a large network in the field of neurology,

•            understand partnering processes and have some experience in partnering with external companies

•            have a proven track record of publications in peer-reviewed, high-quality science journals

•            be open to innovation and driven by science

•            be able to clearly communicate scientific content in management committees

•            have the capacity to understand/deduce partner’s view and situation

•            have the necessary skills to work in a multidisciplinary environment (research, clinical, BD, legal, IP, ….)

•            have an adaptive sense for change management and for influencing the organization

•            be fluent in English (spoken and written), the official language for meetings and reporting

To apply please go to www.ucb.com/careers.

About us.

UCB- Inspired by Patients. Driven by Science. Everything we do starts with a simple question: “How will this create value for people living with severe diseases?” By putting patients at the heart of what we do, our approach – from discovery to development to delivery – is continuously transformed and designed around patient needs and their journey.

With a team of approximately 7,500 employees and operations in more than 40 countries, we are a global biopharmaceutical company investing more than a quarter of our revenue in cutting-edge scientific research. We are focused on addressing chronic, neurological, immunological, and bone diseases.

Curious to know more? Please visit our website www.ucb.com.

UCB and its subsidiaries encourage diversity and inclusion in the workplace; we are an Equal Opportunity Employer. 

About the Center 

The VIB Center for Structural Biology houses research groups with strong expertise in protein biochemistry, X-ray crystallography, NMR, biophysics, nanobody technology, and electron microscopy.  Our department tightly collaborates with other VIB departments (www.vib.be) on cutting edge biological research problems ranging from human diseases to plant biotechnology.

Job description

The VIB Center for Structural Biology (CSB) in Brussels seeks to recruit a Cryo-electron Microscopy (cryo-EM) scientist to support and develop single-particle and tomography projects.

The research scientist will be appointed to the VIB-VUB facility for Bio Electron Cryogenic Microscopy (BECM, www.becm.be), which serves as a technology platform for CSB.

BECM has a state-of-the-art facility for cryo-electron microscopy and houses a JEOL cryoARM300 equipped with an in-column energy filter, phase plate, and K3 detector and is complemented by two screening JEOL JEM-1400 120 kV microscopes. The facility was established in 2018 and serves a large community of users including users from VIB, Belgium, and Europe from academia and industry.

Key responsibilities

• Support a range of cryo-EM projects through interaction with CSB and external scientists
• Contribute to the maintenance of the microscopes
• Contribute to the development of single-particle cryo-EM and/or implementation and development for state-of-the-art tomography
• Provide user training in experimental and computational aspects of cryo-EM

Profile

Key Experience and competences

• Master degree in Natural Sciences or higher
• At least two years of work experience in electron microscopy
• Basic knowledge of Linux and programming skills
• Good communication skills in English

Desirable

• Experience in structural biology
• Experience in single-particle or cryo-tomography data collection and analysis
• Flexible working practice
• Ability to troubleshoot
• Experience with multi-user facilities

How to apply?

Motivated candidates are asked to apply online.

Deadline until a suitable candidate is found.

For further inquiries please contact Marcus Fislage (

marcus.fislage@vub.vib.be

Help us transform patients' lives.

At UCB, we put our heart, soul, and skills into making a difference for people living with severe disease. Working together to push the boundaries, we blend the best of our talents to unlock innovation.  Will you join us in our pioneering adventure?

To strengthen our Upstream Process Sciences Team, basedin Braine, Belgium we are looking for a talented individual to fill the position of:Upstream Process Sciences Group Leader.

As anUpstream Process Sciences Group Leader, your main responsibilities are:

• To contribute defining the strategy and the team for late stage upstream process development of our UCB’s therapeutic protein molecules.

• To define, develop and implement advanced principles and techniques for the process development and production of large molecule therapeutics.

• To manage a diverse and dynamic workforce of scientists/team.

• To collaborate with internal and external partner functions in New Medicines (research), Biotechnological Process Sciences, Technical Operations and Contract Manufacturing Organizations.

• To build and maintain effective collaborations with contract manufacturing organizations, external suppliers and academic network.

• To liaise and promote the technical and scientific exchange with other process development groups and partner departments.

• To apply UCB’s health safety and environment policies and rigorous standards. Participate in continuous improvements of HSE by conformance checks on laboratory set-up, construction and organization as well as day-to-day standards and procedures in close collaboration with the HSE department.

• To ensure:

• Upstream process development and characterization of UCB’s protein molecules.
• Support CMC regulatory filings for cell culture processes.
• Material supply for toxicology studies.
• Deep scientific support for investigations, post-launch process enhancements, technology transfers and the development and characterization of next generation processes post-approval.
• Timely delivery of process characterization, support for scale up and scale down, as well as validation support.
• Innovation for upstream process sciences to offer leading edge manufacturing process options. Define the biopharmaceutical upstream processes of the future.
• Definition of upstream process control strategies.

• To participate in the transfer of processes from small scale development units to the pilot plant and to commercial manufacturing sites.

• To utilize process and laboratory derived data to support technical investigations and aide in process optimization/development.

• To supervise and perform daily laboratory activities relating to media making, cell banking, inoculum and fermentation/cell culture process development and characterization as well as in process analytical methods. Provide technical expertise in matters regarding cell culture process development.

• To author and/or review technical reports, process summaries, protocols, and quantitative analyses for regulatory filings.

Interested? For this position you’ll need the followingeducation, experienceand skills:

• Phd’s or Master’s preferred.
• At least 5 years of experience in a similar role with upstream bio-processing, particularly involving yield improvements and including systematic trouble-shooting.
• Proven track record of drug substance commercialization and manufacturing science & technology, technology transfer expertise for monoclonal antibodies.
• Working knowledge of downstream & analytics.
• Fluent in English, both spoken and written. Good knowledge in French.

Soft skills:

• Very good communication skills in order to maintain good working relationships with internal customers and external customers.
• Strong collaborative and motivational skills.
• Ability to manage multiple programs in matrix environment.
• Ability to work strategically as well as in a detail-oriented framework.
• Ability to lead problem solving for process issues relating to upstream processes.
• Ability to prioritise project work and make effective use of available resource to meet agreed timelines.
• Ability to author and approve comprehensive and accurate protocols/reports.
• Ability to select, implement and use appropriate data management concepts and tools.

Why you should apply

At UCB, we strive to attract passionate and outstanding talents who thrive on change and are ready to bring real value to patients. Working for us you’ll discover a place where you can grow and express your full potential. We place an emphasis on innovation, collaboration and impact. Through meaningful recognition and a motivating work atmosphere, we aim to provide an optimal experience by caring about and valuing our employees – just as we do for the patients we serve.

If you believe you are the perfect match to join us on our pioneering adventure, then we invite you to apply and tell us more about your profile and motivation.

About us.

UCB- Inspired by Patients. Driven by Science. Everything we do starts with a simple question: “How will this create value for people living with severe diseases?” By putting patients at the heart of what we do, our approach – from discovery to development to delivery – is continuously transformed and designed around patient needs and their journey.

With a team of approximately 7,500 employees and operations in more than 40 countries, we are a global biopharmaceutical company investing more than a quarter of our revenue in cutting-edge scientific research. We are focused on addressing chronic, neurological, immunological, and bone diseases.

Curious to know more? Please visit our website www.ucb.com.

UCB and its subsidiaries encourage diversity and inclusion in the workplace; we are an Equal Opportunity Employer. 

Help us transform patients' lives.

At UCB, we put our heart, soul, and skills into making a difference for people living with severe disease. Working together to push the boundaries, we blend the best of our talents to unlock innovation.  Will you join us in our pioneering adventure?

At UCB, every day starts like: “how can I help to improve the lives of patients living with severe diseases”. We also recognize that data and technology are instrumental in the way we invent, develop, manufacture and market our innovative solutions to deliver patient value and improve patient experience in new and ambitious ways.

Within the global UCB IT organization, the mission of the Core Clinical Systems team is to accelerate and transform the way UCB delivers differentiated patient solutions, by implementing and maintaining state-of-the-art clinical development systems.

We are looking for a unique individual to strengthen our team.

As IT Solution Expert Clinical Systems, you will manage and improve core clinical systems to meet the needs of the accelerating and transforming clinical development processes. This includes creating new automated data flows to increase the data available, speed of access and the capability to gain insights from data. Also, you will ensure that the core clinical systems are kept in a validated and inspection-ready state throughout constant changes. You will collaborate with key stakeholders across the clinical development life cycle and various IT teams in Europe, the USA and Asia.

You will be based in Braine-l’Alleud (Belgium).

You see yourself immediately when reading…

•    Bachelor’s or master’s degree in IT, engineering, natural sciences or equivalent, preferably experience in the pharmaceutical industry
•    Ideally experience in project management, process design, computerized system validation, system maintenance, change management, testing, incident-, access-, knowledge management
•    Ideally experience with electronic data capture, clinical data management, clinical trial management and trial master file management
•    You are passionate about technology and application of it to advance healthcare and improve the lives of patients
•    Cross functional team player engaging stakeholders in value creation in a globally diverse cultural environment
•    You love to drive innovation and curiosity is how you learn
•    Open to big challenge and challenging the "as is" state
•    Your attention to details ensures UCB's core clinical systems operate flawlessly
•    Market our value: You can qualify and quantify the benefits of solutions/systems/products and showcase this
•    Fluent in English

Why you should apply

Do you want to contribute in bringing real value to patients living with severe diseases while driving innovation forward? 

Join UCB’s dynamic, inspiring and innovative environment and team. You will be recognized for impactful performance via a competitive compensation and benefits package and you will enjoy ample personal development opportunities.

Tell us what makes you the perfect match to our team and join one of the most dynamic & forward-looking IT organizations in the world.

About us.

UCB- Inspired by Patients. Driven by Science. Everything we do starts with a simple question: “How will this create value for people living with severe diseases?” By putting patients at the heart of what we do, our approach – from discovery to development to delivery – is continuously transformed and designed around patient needs and their journey.

With a team of approximately 7,500 employees and operations in more than 40 countries, we are a global biopharmaceutical company investing more than a quarter of our revenue in cutting-edge scientific research. We are focused on addressing chronic, neurological, immunological, and bone diseases.

Curious to know more? Please visit our website www.ucb.com.

UCB and its subsidiaries encourage diversity and inclusion in the workplace; we are an Equal Opportunity Employer. 

FleishmanHillard’s Brussels office is seeking a graduate intern to support its Environment & Chemicals practice.

FleishmanHillard in Brussels is Europe’s leading EU public affairs and communications consultancy. We have an excellent track record of advising blue chip clients as they navigate regulatory, political and policy issues of substantial commercial and societal significance. We advise our clients on the implications of legislative and other policy developments for their organisations, and develop advocacy strategies that help them meet their objectives and enhance their positioning. Our approach hinges on close partnership, offering deep expertise and applying insight as well as creativity to our clients’ issues.  

We are looking for a Graduate intern with an interest to work in the environment & chemicals policy field, to join this established practice and gain professional experience in EU public affairs.

The successful candidate will assist in the implementation of public affairs programmes for market-leading global accounts. Based on his/her daily monitoring of relevant information sources and reporting on key developments, he/she will assist with preparing draft reports, presentations and issue analysis relevant to our clients.

• 6-month paid internship
• Starting date: asap

Experience required

• We are considering postgraduates, and graduate students currently doing their master at university in courses such as political science or business where there is a strong European focus
• Good understanding of EU policymaking and a true interest in environment / chemicals sector

 Skills & Competencies required

• Basic understanding of environment / chemicals sector and of policy issues most impacting that sector
• Excellent oral and written communication in English is a must; fluency in one or more other languages is a plus
• Commitment to the highest standards of service delivery
• Ability to manage multiple issues and deadlines
• Entrepreneurial and creative approach to problem solving
• Ability to build and maintain trusting relationships
• Dynamic, supportive, collaborative and willing team player

Help us transform patients' lives.

At UCB, we put our heart, soul, and skills into making a difference for people living with severe disease. Working together to push the boundaries, we blend the best of our talents to unlock innovation.  Will you join us in our pioneering adventure?

UCB is a leading global pharmaceutical company, dedicated to the research, development and commercialization of innovative pharmaceutical and biotechnology products in the areas of Neuroscience, Immunology and Oncology. The organization employs some 9000 individuals across approximately 40 countries.  UCB is a pharmaceutical company with a size which enables it to deliver a significant drug pipeline, whilst remaining agile and innovative. For our talented scientists there is plenty of scope to influence the pipeline and make a difference to patients and great potential to influence the strategy and drive the science. UCB remains a great opportunity for the individual to get a breadth of experience of the drug pipeline from research through to the clinic, whilst working in a highly collaborative environment to learn, contribute and gain visibility in a scientific and cross-functional setting.

The Translational Biomarkers and Bioanalysis (TBB) Department is positioned within the function of Development Sciences, a division which provides strategy and support to transition novel pharmacological assets, including gene therapy derived assets, from research into the clinic. TBB operate and collaborate closely across the organization to support bioanalysis and biomarker activities. 

We are looking for a dynamic technical leader to drive bioanalytical technology strategy to support UCBs gene therapy portfolio.  The ideal candidate will be a highly motivated self-starter with extensive experience in developing bioanalytical assays across multiple technology platforms used to support biodistribution, vector shedding as well as gene expression and assessment of immunogenicity of gene therapy products in pre-clinical and early clinical development.  The ideal candidate will have a proven track record leading scientific and technical teams in development and validation of PCR and/ or cell based neutralizing immunogenicity assays.  You will also contribute to the technical transfer of assays to external partner laboratories ensuring efficient transfer of assays capable of meeting regulatory standards.  

The successful candidate will have extensive experience, a strong scientific background, good written and verbal communication skills and be able to multi-task effectively and adapt to meet the demands of a fast-paced matrix-team environment. 

The role is based in Belgium in Braine l’Alleud. 

Skills and experience:

Required

• Candidates should have a BSc and preferably a PhD in a biological discipline
• Proven track record as a scientific leader responsible for talent development 
• Extensive and proven experience of working in the area of gene therapy and bioanalysis
• Clear practical expertise in the development of fit-for-purpose analytical methods to assess PK and Immunogenicity for Gene Therapy assets such as,
  • Cell-based methods including Cellular Transduction Inhibition Neutralising antibody assays and ELISPOT.
  • PCR-based methods including qPCR, ddPCR and/or RT-qPCR
  • Other technologies
• Ability to lead a successful team in a dynamic laboratory ensuring delivery of high-quality, key analytical methods, according to project timelines.
• In depth knowledge of regulatory expectations of bioanalytical assays to support gene therapy assets 
• Extensive knowledge in the validation requirements of such assays that can stand up to scrutiny by regulatory authorities
• Demonstrate multi-tasking and adaptability to changing project and organizational priorities, consistently aligning with departmental needs 
• An ability to work in a matrix, disseminate key data and communicate clearly to stakeholders, colleagues and project scientists, discussing ideas, provide constructive challenge and useful feedback
• Proven track record of developing novel solutions in a discovery, and preferably a clinical setting
• Demonstrated ability to generate, analyse and present critical data sets in collaboration with statisticians and other colleagues
• A keen understanding of the impact of biological and assay variability on experimental design and delivery

Preferred

• Experience with AAV-based gene therapy projects and bioanalysis.
• Experience with molecular biology applications such as qPCR, ddPCR, transcriptomics.
• Experience with cell-based assays such as Cellular Transduction Inhibition, ELISPOT.
• Effective ability to progress assets from Research into Clinical Development
• Previous experience of working in a pharmaceutical drug discovery and assay development environment.
• Demonstrating knowledge of the latest regulatory standards and industry best practices.
• An understanding of biomarkers would be a distinct advantage
• Experience working with a wide range of internal stakeholders including Therapeutic Area, Non-Clinical Safety, DMPK, Translational Medicine, Clinical Pharmacologists, Clinical operations and Quality Assurance colleagues.
• Established track record of working with Clinical Research Organizations in support of method development and validation.
• Good working knowledge of neuroscience, immunology and / or cancer biology
• Experience of working as a departmental representative in a project matrix
• Clear grasp of context of use (linking assay requirements to the usage of the data generated) of biological data

Role and Responsibilities:

• You will employ your proven expertise to lead a successful laboratory driving the development and delivery of advanced bioanalytical solutions supporting the implementation of cell-based immunogenicity and genomic PK assessments in support of our Gene Therapy pipeline.
• Provide technical advice and guide the development and characterisation of bioanalytical assays for gene therapy assessts.
• Play a key part in delivering the strategy of the TBB team to ensure and input into the gene therapy strategy
• You will act as subject matter expert, supporting project teams on bioanalytical considerations, and employ your expertise for the development of complex assessments to ensure delivery of high-quality fit-for-purpose assays in a non-regulated environment
  • Develop qPCR assays for measuring pharmacokinetics in a range of non-clinical and clinical sample types 
  • Develop cell-based immunoassays to measure immunogenicity in a range of non-clinical and clinical sample types.
• Work with key stakeholders to ensure prioritization and optimal deployment of technologies
• Represent and align with the objectives of Development Sciences internally and externally in matters relevant to biomarkers and bioanalysis 
• Provide in-depth knowledge of assay development and troubleshoot technical challenges across multiple platforms
• Work within the Bioanalytical area to optimize experimental design, troubleshooting, sample analysis, data interpretation and report generation
• Provide technical expertise on transfer of assays, both internally and to external partners. 
• Work with CROs and other external providers to transfer and deliver key assays to project and study deadlines
• You will have in-depth knowledge of bioanalytical tools to provide scientific and technical input to Project teams, Biomarker teams and Development Sciences teams
• Ensure compliance with all health and safety, HTA, other regulations 
• Maintain an awareness of new / emerging techniques and tools relevant to the field to ensure the group remains state of the art.
• Work with scientists in discovery and the therapeutic areas as well the clinical scientists to develop and implement novel assays
• You will have in-depth knowledge to provide scientific and technical input to Project teams and Development Sciences teams
• Liaise with statistics to ensure optimum design of experiments
• Ensure compliance with all health and safety regulations 
• Develop and grow links with key academic collaborators
• Work within collaborations with external partners, academic institutions, CROs and consultants as required.

About us.

UCB- Inspired by Patients. Driven by Science. Everything we do starts with a simple question: “How will this create value for people living with severe diseases?” By putting patients at the heart of what we do, our approach – from discovery to development to delivery – is continuously transformed and designed around patient needs and their journey.

With a team of approximately 7,500 employees and operations in more than 40 countries, we are a global biopharmaceutical company investing more than a quarter of our revenue in cutting-edge scientific research. We are focused on addressing chronic, neurological, immunological, and bone diseases.

Curious to know more? Please visit our website www.ucb.com.

UCB and its subsidiaries encourage diversity and inclusion in the workplace; we are an Equal Opportunity Employer. 

Help us transform patients' lives.

At UCB, we put our heart, soul, and skills into making a difference for people living with severe disease. Working together to push the boundaries, we blend the best of our talents to unlock innovation.  Will you join us in our pioneering adventure?

Within the global UCB IT organization, the Analytics Centre of Excellence is playing a crucial role in enabling stakeholders from numerous functional domains with efficient and innovative technology solutions in the areas of BI, Analytics and AI.

We are looking for a unique individual to strengthen our team.

As the Analytics Technology Lead, you will lead Global data science, AI and Advanced Analytics platforms management, integration and innovation. The role is based in Brussels, Belgium.

Your main responsibilities

As the Analytics Technology Lead, you will:

• Manage the Lifecyle of Advanced Analytics platforms and their integration with other analytics platforms.
• Be responsible for defining the advanced analytics technology platform roadmap and in charge of the maintainability and the scalability of the proposed solutions.
• Manage the Rstudio, RShiny, Jupyter and other data science enterprise platforms and labs on premises and in the cloud (AWS and Azure), own the administration of such platforms and supervise the platform administration activities.
• Manage the coordination and the integration of heterogeneous environments in line with the needs of end user and data scientists.
• Lead the platform implementations/projects and manage the stakeholders and vendors involved, by showing advanced project management skills and ability to deliver technology projects in a matrix organization collaborating with the various departments involved like security, technology strategy and infrastructure.

You see yourself immediately when reading…

• Eager to learn, discover and develop new Artificial Intelligence technologies and enable the integration across the different solutions.
• Proficiency in concepts like statistical programming (e.g. R, Python), machine learning, smart data visualization (e.g. R-Shiny, Qlik Sense) and augmented analytics is required.
• Familiar with frameworks involving structured and unstructured data (e,g. Hadoop, Spark, Relational and non-Relational databases).
• Proficient with the management of Linux environments, Containers and knowledgeable of Kubernetes.
• Good communication skills, team player.
• Fluent in English

Why you should apply

Do you want to contribute in bringing real value to patients living with severe diseases while driving innovation forward?

Join UCB’s dynamic, inspiring and innovative environment. You will be recognized for impactful performance via a competitive compensation and benefits package and you will enjoy ample personal development opportunities.

Tell us what makes you the perfect match to our team and join one of the most dynamic & forward-looking IT organizations in the world.

About us.

UCB- Inspired by Patients. Driven by Science. Everything we do starts with a simple question: “How will this create value for people living with severe diseases?” By putting patients at the heart of what we do, our approach – from discovery to development to delivery – is continuously transformed and designed around patient needs and their journey.

With a team of approximately 7,500 employees and operations in more than 40 countries, we are a global biopharmaceutical company investing more than a quarter of our revenue in cutting-edge scientific research. We are focused on addressing chronic, neurological, immunological, and bone diseases.

Curious to know more? Please visit our website www.ucb.com.

UCB and its subsidiaries encourage diversity and inclusion in the workplace; we are an Equal Opportunity Employer.